CORO1C

Coronin-1C is a protein that in humans is encoded by the CORO1C gene.^[5][6][7]

AliasesCORO1C, HCRNN4, coronin 1C

External IDsOMIM: 605269; MGI: 1345964; HomoloGene: 56537; GeneCards: CORO1C; OMA:CORO1C - orthologs

Chr.Chromosome 12 (human)^[1]

End108,731,526 bp^[1]

Quick facts Identifiers, Aliases ...

CORO1C
Identifiers
Aliases	CORO1C, HCRNN4, coronin 1C
External IDs	OMIM: 605269; MGI: 1345964; HomoloGene: 56537; GeneCards: CORO1C; OMA:CORO1C - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 108,645,109 bp[1] End 108,731,526 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 113,980,497 bp[2] End 114,046,819 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein tendon of biceps brachii ganglionic eminence synovial joint Achilles tendon stromal cell of endometrium epithelium of colon urethra popliteal artery tibial arteries Top expressed in stroma of bone marrow corneal stroma ventricular zone yolk sac somite ileum epiblast intestinal villus ganglionic eminence crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding protein binding actin binding Cellular component cytoplasm vesicle cell projection lateral plasma membrane membrane focal adhesion plasma membrane flotillin complex actin cytoskeleton cytoskeleton lamellipodium Biological process regulation of protein phosphorylation negative regulation of protein phosphorylation positive regulation of lamellipodium morphogenesis activation of GTPase activity establishment of protein localization regulation of epithelial cell migration neural crest cell migration negative regulation of protein kinase activity by regulation of protein phosphorylation phagocytosis regulation of focal adhesion assembly regulation of ruffle assembly negative regulation of substrate adhesion-dependent cell spreading regulation of fibroblast migration regulation of substrate adhesion-dependent cell spreading negative regulation of focal adhesion assembly negative regulation of epithelial cell migration actin cytoskeleton organization signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23603 23790 Ensembl ENSG00000110880 ENSMUSG00000004530 UniProt Q9ULV4 Q9WUM4 RefSeq (mRNA) NM_001105237 NM_001276471 NM_014325 NM_011779 RefSeq (protein) NP_001098707 NP_001263400 NP_055140 NP_035909 Location (UCSC) Chr 12: 108.65 – 108.73 Mb Chr 5: 113.98 – 114.05 Mb PubMed search [3] [4]
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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.^[7]