COUP-TFII

NR2F2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CJW
Identifiers
Aliases	NR2F2, ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2, COUP-TFII, nuclear receptor subfamily 2 group F member 2, COUPTF2, ARP-1, SRXX5
External IDs	OMIM: 107773; MGI: 1352452; HomoloGene: 7628; GeneCards: NR2F2; OMA:NR2F2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	96,340,263 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	70,016,483 bp
RNA expression pattern
	Top expressed in
	urethra; ; cardia; ; spinal ganglia; ; renal medulla; ; trigeminal ganglion; ; right ovary; ; stromal cell of endometrium; ; decidua; ; seminal vesicula; ; saphenous vein;
	Top expressed in
	Gonadal ridge; ; genital tubercle; ; vas deferens; ; gastrula; ; stroma of kidney; ; ascending aorta; ; sciatic nerve; ; anterior amygdaloid area; ; epithelium of stomach; ; aortic valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; retinoic acid binding; protein homodimerization activity; transcription corepressor activity; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	trophoblast giant cell differentiation; response to estradiol; regulation of transcription, DNA-templated; blood vessel morphogenesis; negative regulation of cyclin-dependent protein serine/threonine kinase activity; lipid metabolism; regulation of transcription by RNA polymerase II; placenta blood vessel development; radial pattern formation; neuron migration; in utero embryonic development; negative regulation of transcription by RNA polymerase II; lymph vessel development; transcription, DNA-templated; negative regulation of endothelial cell migration; limb development; negative regulation of endothelial cell proliferation; positive regulation of transcription, DNA-templated; maternal placenta development; fertilization; forebrain development; negative regulation of transcription, DNA-templated; skeletal muscle tissue development; signal transduction; anterior/posterior pattern specification; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; positive regulation of systemic arterial blood pressure;
	Sources:Amigo / QuickGO
Orthologs
	7026
	11819
	ENSG00000185551
	ENSMUSG00000030551
	P24468
	P43135
	NM_021005; NM_001145155; NM_001145156; NM_001145157
	NM_009697; NM_183261
	NP_001138627; NP_001138628; NP_001138629; NP_066285
	NP_033827; NP_899084
	Wikidata
View/Edit Human	View/Edit Mouse

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.^[5]^[6] The COUP acronym stands for chicken ovalbumin upstream promoter.

PDBOrtholog search: PDBe RCSB

AliasesNR2F2, ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2, COUP-TFII, nuclear receptor subfamily 2 group F member 2, COUPTF2, ARP-1, SRXX5

External IDsOMIM: 107773; MGI: 1352452; HomoloGene: 7628; GeneCards: NR2F2; OMA:NR2F2 - orthologs

Chr.Chromosome 15 (human)^[1]

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COUP-TFII

Function

Structure and ligands

Interactions

References

External links

Further reading

Related Articles

Related Articles

"The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development"

"The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development"

"Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism"

"The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis"

"Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor"

"Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2"

"Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells"

"Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells"

"The COUP-TFs compose a family of functionally related transcription factors"

"The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD"

"Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors"

"Functional Proteomics Mapping of a Human Signaling Pathway"