CP-809101

CP-809101 is a drug which acts as a potent and highly selective serotonin 5-HT_2C receptor full agonist.^[1] It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.^[2][3]

ATC code

• None

CAS Number

• 479683-64-2 ^Y

PubChem CID

• 9901086

ChemSpider

• 8076740 ^N

Quick facts Clinical data, ATC code ...

CP-809101

Clinical data
ATC code	None
Identifiers
IUPAC name 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine
CAS Number	479683-64-2 Y
PubChem CID	9901086
ChemSpider	8076740 N
UNII	A2EXW95647
CompTox Dashboard (EPA)	DTXSID60197369
Chemical and physical data
Formula	C15H17ClN4O
Molar mass	304.78 g·mol−1
3D model (JSmol)	Interactive image
SMILES C2CNCCN2c(n3)cncc3OCc(c1)cccc1Cl
InChI InChI=1S/C15H17ClN4O/c16-13-3-1-2-12(8-13)11-21-15-10-18-9-14(19-15)20-6-4-17-5-7-20/h1-3,8-10,17H,4-7,11H2 N Key:PCWGGOVOEWHPMG-UHFFFAOYSA-N N
NY (what is this?)  (verify)

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The drug has more than three orders of magnitude lower potency as an agonist of the serotonin 5-HT_2A receptor compared to the serotonin 5-HT_2C receptor as well as lower efficacy at the receptor in comparison (E_maxTooltip maximal efficacy = 93% and 67%, respectively).^[2] It did not produce the head-twitch response in rodents, and was able to antagonize the head-twitch response induce by the psychedelic drug (–)-DOI.^[2]