CREG1

Protein CREG1 (Cellular Repressor of E1A-stimulated Genes 1) is a protein that in humans is encoded by the CREG1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesCREG1, CREG, cellular repressor of E1A stimulated genes 1

External IDsOMIM: 618055; MGI: 1344382; HomoloGene: 31199; GeneCards: CREG1; OMA:CREG1 - orthologs

Chr.Chromosome 1 (human)^[1]

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CREG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XHN
Identifiers
Aliases	CREG1, CREG, cellular repressor of E1A stimulated genes 1
External IDs	OMIM: 618055; MGI: 1344382; HomoloGene: 31199; GeneCards: CREG1; OMA:CREG1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 167,529,117 bp[1] End 167,553,805 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.3 Start 165,591,315 bp[2] End 165,602,877 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh hair follicle vulva skin of arm gallbladder parotid gland lower lobe of lung skin of hip gingival epithelium trabecular bone Top expressed in blood stroma of bone marrow left lobe of liver epithelium of stomach fetal liver hematopoietic progenitor cell transitional epithelium of urinary bladder saccule otic placode lacrimal gland tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding transcription corepressor activity Cellular component extracellular exosome transcription regulator complex extracellular region extracellular space azurophil granule lumen Biological process regulation of transcription by RNA polymerase II multicellular organism development regulation of growth cell population proliferation regulation of transcription, DNA-templated negative regulation of nucleic acid-templated transcription neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8804 433375 Ensembl ENSG00000143162 ENSMUSG00000040713 UniProt O75629 O88668 RefSeq (mRNA) NM_003851 NM_011804 RefSeq (protein) NP_003842 NP_035934 Location (UCSC) Chr 1: 167.53 – 167.55 Mb Chr 1: 165.59 – 165.6 Mb PubMed search [3] [4]
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The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.^[6]