CRHBP

Corticotropin-releasing factor-binding protein is a protein that in humans is encoded by the CRHBP gene.^[5][6] It belongs to corticotropin-releasing hormone binding protein family.

AliasesCRHBP, CRF-BP, CRFBP, corticotropin releasing hormone binding protein

External IDsOMIM: 122559; MGI: 88497; HomoloGene: 1418; GeneCards: CRHBP; OMA:CRHBP - orthologs

Chr.Chromosome 5 (human)^[1]

End76,981,158 bp^[1]

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CRHBP
Identifiers
Aliases	CRHBP, CRF-BP, CRFBP, corticotropin releasing hormone binding protein
External IDs	OMIM: 122559; MGI: 88497; HomoloGene: 1418; GeneCards: CRHBP; OMA:CRHBP - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 76,953,045 bp[1] End 76,981,158 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 49.5 cM Start 95,567,879 bp[2] End 95,581,432 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad spleen liver right lobe of liver prefrontal cortex testicle left adrenal cortex right adrenal cortex human kidney hypothalamus Top expressed in vestibular membrane of cochlear duct ciliary body iris lens lumbar subsegment of spinal cord hippocampus proper Region I of hippocampus proper visual cortex vestibular sensory epithelium amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function corticotropin-releasing hormone binding protein binding peptide binding Cellular component Golgi apparatus secretory granule endoplasmic reticulum perikaryon axon terminus dense core granule dendrite varicosity secondary lysosome multivesicular body microtubule extracellular region extracellular space intracellular anatomical structure nucleus Biological process negative regulation of corticotropin secretion female pregnancy cellular response to tumor necrosis factor regulation of corticotropin secretion cellular response to estrogen stimulus hormone-mediated signaling pathway behavioral response to ethanol learning or memory regulated exocytosis inflammatory response signal transduction cellular response to potassium ion cellular response to cocaine negative regulation of corticotropin-releasing hormone receptor activity synaptic transmission, dopaminergic maternal aggressive behavior hormone metabolic process cellular response to calcium ion cellular response to cAMP cellular response to estradiol stimulus cellular response to gonadotropin-releasing hormone regulation of NMDA receptor activity regulation of cellular response to stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1393 12919 Ensembl ENSG00000145708 ENSMUSG00000021680 UniProt P24387 Q60571 RefSeq (mRNA) NM_001882 NM_198408 RefSeq (protein) NP_001873 NP_940800 Location (UCSC) Chr 5: 76.95 – 76.98 Mb Chr 13: 95.57 – 95.58 Mb PubMed search [3] [4]
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Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.^[6]