CRMP1

Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.^[5]

PDBOrtholog search: PDBe RCSB

AliasesCRMP1, CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3, collapsin response mediator protein 1

External IDsOMIM: 602462; MGI: 107793; HomoloGene: 20347; GeneCards: CRMP1; OMA:CRMP1 - orthologs

Chr.Chromosome 4 (human)^[1]

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CRMP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B3Z
Identifiers
Aliases	CRMP1, CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3, collapsin response mediator protein 1
External IDs	OMIM: 602462; MGI: 107793; HomoloGene: 20347; GeneCards: CRMP1; OMA:CRMP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.2 Start 5,748,084 bp[1] End 5,893,086 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B3|5 19.96 cM Start 37,399,284 bp[2] End 37,449,477 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone lateral nuclear group of thalamus right hemisphere of cerebellum middle temporal gyrus prefrontal cortex dorsolateral prefrontal cortex right frontal lobe paraflocculus of cerebellum anterior pituitary Top expressed in ganglionic eminence superior cervical ganglion barrel cortex olfactory bulb entorhinal cortex CA3 field perirhinal cortex dentate gyrus of hippocampal formation granule cell medial ganglionic eminence neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds filamin binding Cellular component spindle cytoskeleton microtubule organizing center cytoplasm cytosol midbody centrosome nucleus Biological process neuron development nucleobase-containing compound metabolic process microtubule cytoskeleton organization nervous system development axon guidance negative regulation of actin filament binding negative regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1400 12933 Ensembl ENSG00000072832 ENSMUSG00000029121 UniProt Q14194 P97427 RefSeq (mRNA) NM_001313 NM_001014809 NM_001288661 NM_001288662 NM_001136058 NM_007765 RefSeq (protein) NP_001014809 NP_001275590 NP_001275591 NP_001304 NP_001129530 NP_031791 Location (UCSC) Chr 4: 5.75 – 5.89 Mb Chr 5: 37.4 – 37.45 Mb PubMed search [3] [4]
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This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.^[5]

CRMP1 mediates reelin signaling in cortical neuronal migration.^[6] Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory.^[7]

CRMP1 gene overlaps with another gene called EVC.^[8]