Rootletin
Protein found in humans
From Wikipedia, the free encyclopedia
Rootletin, also known as ciliary rootlet coiled-coil protein (CROCC) is a protein in humans that is encoded by the CROCC gene.[5][6][7] Rootletin is a component of the ciliary rootlet and, together with CEP68 and CEP250, is required for centrosome cohesion.[8]
Rootletin is an important protein in the ciliary rootlet, particularly for the structure and is considered important protein in mitosis as a centrosome linker.
Function
This protein forms part of the ciliary rootlet structure. It also contributes to the centrosome cohesion before mitosis.[9] Expression of rootletin leads to the formation of fibrous protein.
Structure
This protein is part of the structure of a ciliary rootlet. This cytoskeletal-like structure starts from the basal body at one end of the cilium and extends towards the nucleus. Its molecular structure consists of a globular head domain and a tail domain made up of coiled-coil structures.[5]
Protein interactions
A large coiled-coil protein, C-Nap1, is a docking site for the fibrous tether to proximal ends of centrioles which Rootletin physically interacts with. Furthermore, Rootletin is phosphorylated by Nek2 kinase.[10]