CRTC2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesCRTC2, TORC-2, TORC2, CREB regulated transcription coactivator 2
Quick facts Available structures, PDB ...
CRTC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRTC2, TORC-2, TORC2, CREB regulated transcription coactivator 2
External IDsOMIM: 608972; MGI: 1921593; HomoloGene: 18765; GeneCards: CRTC2; OMA:CRTC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181715

NM_028881
NM_001357152

RefSeq (protein)

NP_859066

NP_083157
NP_001344081

Location (UCSC)Chr 1: 153.95 – 153.96 MbChr 3: 90.16 – 90.17 Mb
PubMed search[3][4]
Wikidata
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Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.[8] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).[9]

Interactions

CRTC2 has been shown to interact with SNF1LK2[10] and YWHAQ.[10][11]

References

Further reading

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