CXCL7

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesPPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein

External IDsOMIM: 121010; MGI: 1888712; HomoloGene: 136759; GeneCards: PPBP; OMA:PPBP - orthologs

Chr.Chromosome 4 (human)^[1]

Quick facts PPBP, Available structures ...

PPBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TVX, 1F9P, 1NAP
Identifiers
Aliases	PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
External IDs	OMIM: 121010; MGI: 1888712; HomoloGene: 136759; GeneCards: PPBP; OMA:PPBP - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 73,986,439 bp[1] End 73,988,190 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 90,916,377 bp[2] End 90,917,922 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte trabecular bone granulocyte blood bone marrow cell periodontal fiber spleen decidua right lung testicle Top expressed in tibiofemoral joint umbilical cord blood spleen fetal liver hematopoietic progenitor cell body of femur right lung lobe human fetus endocardial cushion yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity cytokine activity glucose transmembrane transporter activity CXCR chemokine receptor binding chemokine activity protein binding Cellular component platelet alpha granule lumen extracellular region extracellular space tertiary granule lumen platelet alpha granule Biological process response to lipopolysaccharide regulation of cell population proliferation chemotaxis positive regulation of cell division platelet degranulation defense response to bacterium inflammatory response immune response chemokine-mediated signaling pathway defense response positive regulation of neutrophil chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity neutrophil degranulation cell chemotaxis G protein-coupled receptor signaling pathway glucose transmembrane transport neutrophil chemotaxis leukocyte chemotaxis cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5473 57349 Ensembl ENSG00000163736 ENSMUSG00000029372 UniProt P02775 Q9EQI5 RefSeq (mRNA) NM_002704 NM_023785 RefSeq (protein) NP_002695 NP_076274 Location (UCSC) Chr 4: 73.99 – 73.99 Mb Chr 5: 90.92 – 90.92 Mb PubMed search [3] [4]
Wikidata
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The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).^[6]

It is a protein that is released in large amounts from platelets following their activation.^[7] It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.^[8][9]