2C-T-36
Chemical compound
From Wikipedia, the free encyclopedia
2C-T-36, also known as 2,5-dimethoxy-4-(trifluoromethylsulfanyl)phenethylamine or 2C-T-TFM as well as CYB210010 or CYB2108, is a psychedelic drug of the phenethylamine and 2C families.[1][2]
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| Other names | 2C-T-TFM; CYB210010; CYB-210010; CYB-2108; CYB2108; 2,5-Dimethoxy-4-(trifluoromethylsulfanyl)phenethylamine |
| Drug class | Serotonin 5-HT2 receptor agonist; Serotonergic psychedelic; Hallucinogen |
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| Formula | C11H14F3NO2S |
| Molar mass | 281.29 g·mol−1 |
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Use and effects
Interactions
Pharmacology
Pharmacodynamics
2C-T-36 has a Ki of 0.35 nM at the serotonin 5-HT2A receptor, and an EC50 of 4.1 nM at the serotonin 5-HT2A receptor and 7.3 nM at the serotonin 5-HT2C receptor, compared to 88 nM at the serotonin 5-HT2B receptor.[5] It is a potent, selective, long acting, and orally active agonist for the serotonin 5-HT2A and 5-HT2C receptors and produces psychedelic-like responding in several different animal species.[1][2] The interactions of 2C-T-36 with numerous other receptors and targets have also been described.[1]
Chemistry
Synthesis
The chemical synthesis of 2C-T-36 has been described.[3][1]
Analogues
Analogues of 2C-T-36 (2C-T-TFM) include 2C-T-21 (2C-T-FE), 2C-T-21.5 (2C-T-DFE), 2C-T-22 (2C-T-TFE), 2C-T-28 (2C-T-FP), 2C-T-35 (2C-T-DFM), 2C-T, 2C-TFM, and 2C-TFE, among others.[3][4][1] Some other analogues include 2C-Se-TFM, trifluoromescaline (TFM), 3C-TFE (3C-trifluoroescaline), and tiflorex (flutiorex).[4][1] A deuterated isotopologue, CYB2108D (2C-T-36 with fully deuterated methoxy groups at 2 and 5 positions), is known.[6][7]
History
Alexander Shulgin attempted to synthesise this compound in the 1990s, and mentions it in his book PiHKAL (Phenethylamines I Have Known and Loved) under the entry for 2C-T-21, but was unsuccessful in producing a key intermediate and never assigned it a 2C-T number.[3] 2C-T-36 was ultimately first synthesised and named by Geoffrey Varty and colleagues at Irish biopharmaceutical company Helus Pharma (formerly Cybin) in 2023.[2]
Society and culture
Legal status
Canada
2C-T-36 is a controlled substance in Canada under phenethylamine blanket-ban language.[8]
United States
The drug is not an explicitly controlled substance in the United States.[9]
Research
Other related drugs under development by Helus Pharma (formerly Cybin) include the deuterated phenethylamine HLP005 (CYB005) and the deuterated tryptamines HLP003 (CYB003) and HLP004 (CYB004).[10][11]