Cytochrome b5, type A

Cytochrome b5, form A (gene name CYB5A), is a human microsomal cytochrome b5.^[5]

PDBOrtholog search: PDBe RCSB

AliasesCYB5A, CYB5, MCB5, Cytochrome b5, type A, cytochrome b5 type A, METAG

External IDsOMIM: 613218; MGI: 1926952; HomoloGene: 41475; GeneCards: CYB5A; OMA:CYB5A - orthologs

Chr.Chromosome 18 (human)^[1]

Quick facts CYB5A, Available structures ...

CYB5A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I96
Identifiers
Aliases	CYB5A, CYB5, MCB5, Cytochrome b5, type A, cytochrome b5 type A, METAG
External IDs	OMIM: 613218; MGI: 1926952; HomoloGene: 41475; GeneCards: CYB5A; OMA:CYB5A - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q22.3 Start 74,250,846 bp[1] End 74,291,973 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E4|18 57.53 cM Start 84,856,829 bp[2] End 84,897,996 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule right lobe of liver renal medulla glomerulus pancreatic ductal cell jejunal mucosa metanephric glomerulus body of pancreas gallbladder human kidney Top expressed in right kidney olfactory epithelium proximal tubule gallbladder transitional epithelium of urinary bladder human kidney gastrula iris left lobe of liver decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytochrome-c oxidase activity aldo-keto reductase (NADP) activity metal ion binding heme binding enzyme binding Cellular component organelle membrane integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle mitochondrial outer membrane endoplasmic reticulum mitochondrion extracellular exosome cytoplasm cytosol Biological process response to cadmium ion L-ascorbic acid metabolic process proton transmembrane transport electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1528 109672 Ensembl ENSG00000166347 ENSMUSG00000024646 UniProt P00167 P56395 RefSeq (mRNA) NM_001190807 NM_001914 NM_148923 NM_025797 NM_001348159 RefSeq (protein) NP_001177736 NP_001905 NP_683725 NP_080073 NP_001335088 Location (UCSC) Chr 18: 74.25 – 74.29 Mb Chr 18: 84.86 – 84.9 Mb PubMed search [3] [4]
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Cytochrome b5 is a membrane bound hemoprotein which functions as an electron carrier for several membrane bound oxygenases. It has two isoforms produced by alternative splicing. Isoform 1 is bound to the cytoplasmic side of the endoplasmic reticulum. It has a C-terminal transmembrane alpha-helix. Isoform 2 was found in cytoplasm. Defects in CYB5A are the cause of type IV hereditary methemoglobinemia.