CYP2A13

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesCYP2A13, CPAD, CYP2A, CYPIIA13, cytochrome P450 family 2 subfamily A member 13

External IDsOMIM: 608055; MGI: 88597; HomoloGene: 85917; GeneCards: CYP2A13; OMA:CYP2A13 - orthologs

Chr.Chromosome 19 (human)^[1]

Quick facts Available structures, PDB ...

CYP2A13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P85, 2PG5, 2PG6, 2PG7, 3T3S, 4EJG, 4EJH, 4EJI
Identifiers
Aliases	CYP2A13, CPAD, CYP2A, CYPIIA13, cytochrome P450 family 2 subfamily A member 13
External IDs	OMIM: 608055; MGI: 88597; HomoloGene: 85917; GeneCards: CYP2A13; OMA:CYP2A13 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,088,451 bp[1] End 41,096,195 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 15.54 cM Start 26,534,730 bp[2] End 26,542,973 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium olfactory zone of nasal mucosa Brodmann area 10 quadriceps femoris muscle paraflocculus of cerebellum mucosa of paranasal sinus middle frontal gyrus frontal pole epithelium of bronchus bronchial epithelial cell Top expressed in proximal tubule human kidney right kidney hepatobiliary system liver esophagus respiratory epithelium thymus nasal epithelium olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxidoreductase activity aromatase activity arachidonic acid epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding coumarin 7-hydroxylase activity steroid hydroxylase activity monooxygenase activity Cellular component organelle membrane endoplasmic reticulum membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle cytoplasm Biological process xenobiotic metabolic process epoxygenase P450 pathway coumarin metabolic process organic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1553 13087 Ensembl ENSG00000197838 ENSMUSG00000005547 UniProt Q16696 P20852 RefSeq (mRNA) NM_000766 NM_007812 RefSeq (protein) NP_000757 n/a Location (UCSC) Chr 19: 41.09 – 41.1 Mb Chr 7: 26.53 – 26.54 Mb PubMed search [3] [4]
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.^[7]