Carbarsone

Chemical compound From Wikipedia, the free encyclopedia

Carbarsone is an organoarsenic compound used as an antiprotozoal drug for treatment of amebiasis and other infections.[1][2][3] It was available for amebiasis in the United States as late as 1991. Thereafter, it remained available as a turkey feed additive for increasing weight gain and controlling histomoniasis (blackhead disease).[4][5]

Quick facts Names, Identifiers ...
Carbarsone
Names
Preferred IUPAC name
[4-(Carbamoylamino)phenyl]arsonic acid
Other names
(4-Ureidophenyl)arsonic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.004.077 Edit this at Wikidata
EC Number
  • 204-484-6
MeSH Carbarson
UNII
  • InChI=1S/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14) checkY
    Key: WWXBHTZSYYGCSG-UHFFFAOYSA-N checkY
  • InChI=1/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14)
    Key: WWXBHTZSYYGCSG-UHFFFAOYAW
  • O=C(Nc1ccc(cc1)[As](=O)(O)O)N
  • NC(=O)NC1=CC=C(C=C1)[As](O)(O)=O
Properties
C7H9AsN2O4
Molar mass 260.081 g·mol−1
Pharmacology
Oral
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Carbarsone is one of four arsenical animal drugs approved by the U.S. Food and Drug Administration for use in poultry and/or swine, along with nitarsone, arsanilic acid, and roxarsone.[6] In September 2013, the FDA announced that Zoetis and Fleming Laboratories would voluntarily withdraw current roxarsone, arsanilic acid, and carbarsone approvals, leaving only nitarsone approvals in place.[7] In 2015 FDA withdrew the approval of using nitarsone in animal feeds. The ban came into effect at the end of 2015.[8]

References

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