CatSper1

CATSPER1
Identifiers
Aliases	CATSPER1, CATSPER, SPGF7, CatSper1, cation channel sperm associated 1
External IDs	OMIM: 606389; MGI: 2179947; HomoloGene: 14207; GeneCards: CATSPER1; OMA:CATSPER1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,026,479 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,394,308 bp
RNA expression pattern
	Top expressed in
	testicle; ; monocyte; ; granulocyte; ; left testis; ; right testis; ; Descending thoracic aorta; ; ascending aorta; ; blood; ; popliteal artery; ; tibial arteries;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium activated cation channel activity; calcium channel activity; voltage-gated ion channel activity; ion channel activity; protein binding; high voltage-gated calcium channel activity; voltage-gated calcium channel activity;
Cellular component	integral component of membrane; CatSper complex; cell projection; membrane; plasma membrane; cilium; motile cilium;
Biological process	cell differentiation; membrane depolarization during action potential; regulation of ion transmembrane transport; ion transport; multicellular organism development; calcium ion transmembrane transport; transmembrane transport; spermatogenesis; sperm-egg recognition; calcium ion transport; flagellated sperm motility; regulation of cilium beat frequency involved in ciliary motility; response to progesterone;
	Sources:Amigo / QuickGO
Orthologs
	117144
	225865
	ENSG00000175294
	ENSMUSG00000038498
	Q8NEC5
	Q91ZR5
	NM_053054
	NM_139301
	NP_444282
	NP_647462
	Wikidata
View/Edit Human	View/Edit Mouse

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.^[5]^[6]^[7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[8]