CatSper4

CATSPER4
Identifiers
Aliases	CATSPER4, CatSper4, cation channel sperm associated 4
External IDs	OMIM: 609121; MGI: 3043288; HomoloGene: 18638; GeneCards: CATSPER4; OMA:CATSPER4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,202,968 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,954,694 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; mucosa of transverse colon; ; right uterine tube; ; lobe of thyroid gland; ; left lobe of thyroid gland; ; tibial nerve;
	Top expressed in
	spermatid; ; testicle; ; spermatocyte; ; muscle of thigh; ; neural layer of retina; ; embryo; ; muscle tissue; ; quadriceps femoris muscle; ; jejunum; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated calcium channel activity; calcium activated cation channel activity; calcium channel activity; voltage-gated ion channel activity; ion channel activity; NAADP-sensitive calcium-release channel activity;
Cellular component	integral component of membrane; CatSper complex; cell projection; membrane; plasma membrane; cilium; sperm principal piece; acrosomal vesicle; motile cilium;
Biological process	flagellated sperm motility; cell differentiation; membrane depolarization during action potential; sodium ion transport; regulation of ion transmembrane transport; ion transport; multicellular organism development; calcium ion transmembrane transport; transmembrane transport; spermatogenesis; sperm-egg recognition; sperm capacitation; release of sequestered calcium ion into cytosol; calcium ion transport; response to progesterone;
	Sources:Amigo / QuickGO
Orthologs
	378807
	329954
	ENSG00000188782
	ENSMUSG00000048003
	Q7RTX7
	Q8BVN3
	NM_198137
	NM_001130030; NM_177866
	NP_937770
	NP_001123502; NP_808534
	Wikidata
View/Edit Human	View/Edit Mouse

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene.^[5]^[6]^[7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[8]