Centpropazine

Centpropazine
Clinical data
Other names	CPZ; CTZ
Routes of; administration	Oral
Identifiers
	IUPAC name 1-[4-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]phenyl]propan-1-one;
CAS Number	91315-34-3;
PubChem CID	118176;
ChemSpider	105612;
UNII	R5YPG9LA47;
ChEMBL	ChEMBL4303166;
CompTox Dashboard (EPA)	DTXSID00919825 ;
Chemical and physical data
Formula	C22H28N2O3
Molar mass	368.477 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(=O)C1=CC=C(C=C1)OCC(CN2CCN(CC2)C3=CC=CC=C3)O;
	InChI InChI=1S/C22H28N2O3/c1-2-22(26)18-8-10-21(11-9-18)27-17-20(25)16-23-12-14-24(15-13-23)19-6-4-3-5-7-19/h3-11,20,25H,2,12-17H2,1H3; Key:ZQPXSRTZFYHSFB-UHFFFAOYSA-N;

Centpropazine (CPZ, CTZ) is an experimental antidepressant of the phenylpiperazine family which was under development for the treatment of major depressive disorder in India but was never marketed.^[1]^[2]^[3] It is described as having imipramine-like clinical effects, reversing reserpine-induced effects in animals, and potentiating amphetamine-induced effects in animals.^[3] The mechanism of action of centpropazine is unknown.^[4] The drug reached phase 3 clinical trials prior to the discontinuation of its development.^[1] It was first described in the scientific literature by 1980.^[3]^[5]

Chemical structures of centpropazine and analogues

Other namesCPZ; CTZ

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Clinical data

Other names	CPZ; CTZ
Routes of administration	Oral^[1]
Identifiers
IUPAC name 1-[4-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]phenyl]propan-1-one
CAS Number	91315-34-3
PubChem CID	118176
ChemSpider	105612
UNII	R5YPG9LA47
ChEMBL	ChEMBL4303166
CompTox Dashboard (EPA)	DTXSID00919825
Chemical and physical data
Formula	C₂₂H₂₈N₂O₃
Molar mass	368.477 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCC(=O)C1=CC=C(C=C1)OCC(CN2CCN(CC2)C3=CC=CC=C3)O
InChI InChI=1S/C22H28N2O3/c1-2-22(26)18-8-10-21(11-9-18)27-17-20(25)16-23-12-14-24(15-13-23)19-6-4-3-5-7-19/h3-11,20,25H,2,12-17H2,1H3 Key:ZQPXSRTZFYHSFB-UHFFFAOYSA-N