Cetiedil

Chemical compound From Wikipedia, the free encyclopedia

Cetiedil is a vasodilator and an anti-sickling agent.[1]

ATC code
CAS Number
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Cetiedil
Clinical data
ATC code
Identifiers
  • 2-(azepan-1-yl)ethyl 2-cyclohexyl-2-(thiophen-3-yl)acetate
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ECHA InfoCard100.034.556 Edit this at Wikidata
Chemical and physical data
FormulaC20H31NO2S
Molar mass349.53 g·mol−1
3D model (JSmol)
  • O=C(OCCN1CCCCCC1)C(c2ccsc2)C3CCCCC3
  • InChI=1S/C20H31NO2S/c22-20(23-14-13-21-11-6-1-2-7-12-21)19(18-10-15-24-16-18)17-8-4-3-5-9-17/h10,15-17,19H,1-9,11-14H2 ☒N
  • Key:MMNICIJVQJJHHF-UHFFFAOYSA-N ☒N
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Synthesis

Thieme Original patents:[2] Prepn and activity:[3] Revised synthesis:[4][5] Analogues:[6]

The Clemmensen reduction of 3-thienylcyclohexyl-glycolic acid, CID:11064522 (1) gives cyclohexyl(thiophen-3-yl)acetic acid [16199-74-9] (2). Esterification of the sodium salt of the resulting acid with 1-(2-chloroethyl)azepane [2205-31-4] (3) produces cetiedil (4).

References

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