Clevudine

Clevudine (INN) is an antiviral drug for the treatment of hepatitis B (HBV). It is already approved for HBV in South Korea and the Philippines. It is marketed by Bukwang Pharmaceuticals in South Korea under the tradenames Levovir and Revovir.

Routes of
administrationOral

ATC code

• J05AF12 (WHO) ^[1]

CAS Number

• 163252-36-6 ^Y
• active moiety: 69256-17-3 ^Y

PubChem CID

• 73115

Quick facts Clinical data, Routes ofadministration ...

Clevudine

Clinical data
Routes of administration	Oral
ATC code	J05AF12 (WHO) [1]
Identifiers
IUPAC name 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5- (hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine- 2,4-dione
CAS Number	163252-36-6 Y active moiety: 69256-17-3 Y
PubChem CID	73115
ChemSpider	65894 N
UNII	IN51MVP5F1 active moiety: 37F7D05ANB Y
KEGG	D03537 Y
ChEMBL	ChEMBL458875 N
CompTox Dashboard (EPA)	DTXSID2057659
Chemical and physical data
Formula	C10H13FN2O5
Molar mass	260.221 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C/1NC(=O)N(\C=C\1C)[C@H]2O[C@H]([C@H](O)[C@H]2F)CO
InChI InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1 N Key:GBBJCSTXCAQSSJ-XQXXSGGOSA-N N
NY (what is this?)  (verify)

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Researchers in South Korea are testing clevudine at lower doses in combination with adefovir for continued use.^[2]

It is a nucleoside analog.^[3]