CNKSR1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesCNKSR1, CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
Quick facts Available structures, PDB ...
CNKSR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNKSR1, CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
External IDsOMIM: 603272; MGI: 2670958; HomoloGene: 4604; GeneCards: CNKSR1; OMA:CNKSR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001297647
NM_001297648
NM_006314

NM_001081047

RefSeq (protein)

NP_001284576
NP_001284577
NP_006305

NP_001074516

Location (UCSC)Chr 1: 26.18 – 26.19 MbChr 4: 133.96 – 133.97 Mb
PubMed search[3][4]
Wikidata
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Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.[6]

Interactions

CNKSR1 has been shown to interact with RhoD[7] and RASSF1.[8]

References

Further reading

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