Corbadrine
Chemical compound
From Wikipedia, the free encyclopedia
Corbadrine, sold under the brand name Neo-Cobefrine and also known as levonordefrin and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States.[1][2][3] It is usually used in a pre-mixed solution with local anesthetics, such as mepivacaine.[4]
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- In general: ℞ (Prescription only)
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| Trade names | Neo-Cobefrine |
| Other names | Levonordefrin; α-Methylnorepinephrine; (–)-3,4-Dihydroxynorephedrine; 3,4,β-Trihydroxy-α-methylphenethylamine; 3,4,β-Trihydroxyamphetamine |
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| ECHA InfoCard | 100.113.606 |
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| Formula | C9H13NO3 |
| Molar mass | 183.207 g·mol−1 |
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The drug acts as a non-selective agonist of the α1-, α2-, and β-adrenergic receptors.[5][6][7] It is said to have preferential activity at the α2-adrenergic receptor.[5][7]
Corbadrine is also a metabolite of the antihypertensive drug methyldopa and plays a role in its pharmacology and effects.[8]
Pharmacology
Pharmacokinetics
Corbadrine is metabolized primarily by catechol O-methyltransferase (COMT).[7]
Chemistry
Corbadrine, also known as 3,4,β-trihydroxy-α-methylphenethylamine or as 3,4,β-trihydroxyamphetamine, as well as α-methylnorepinephrine or (–)-3,4-dihydroxynorephedrine, is a substituted phenethylamine and amphetamine derivative.[1][3]
Analogues of corbadrine include α-methyldopamine, dioxifedrine (3,4-dihydroxyephedrine; α-methylepinephrine), dioxethedrin (3,4-dihydroxy-N-ethylnorephedrine; α-methyl-N-ethylnorepinephrine), and hydroxyamphetamine (4-hydroxyamphetamine; α-methyltyramine).