Coriamyrtin
Convulsant toxin
From Wikipedia, the free encyclopedia
Coriamyrtin is a toxic γ-lactone naturally present in a multitude of plants.
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| Names | |
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| IUPAC name
(1S,2R,3S,5R,6R,7R,9S,12R)-2-Hydroxy-7-methyl-12-prop-1-en-2-ylspiro[4,10-dioxatetracyclo[7.2.1.02,7.03,5]dodecane-6,2'-oxirane]-11-one | |
| Other names
Coriamyrtine | |
| Identifiers | |
3D model (JSmol) |
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PubChem CID |
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CompTox Dashboard (EPA) |
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| Properties | |
| C15H18O5 | |
| Molar mass | 278.304 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Natural occurrence
Coriamyrtin can be found in Scurrula parasitica,[2] Coriaria microphylla,[3] Coriaria nepalensis,[4] and certain other plants.
Toxicity
Coriamyrtin is a convulsant.[5] It appears to act via antagonism of GABAA receptors.[6] Poisoning is usually from ingestion of parts of the plants containing it. A case of poisoning was able to be treated with repeated administration of diazepam, an anticonvulsant.[4]