Cubilin
Mammalian protein found in humans
From Wikipedia, the free encyclopedia
Cubilin is a protein that in humans is encoded by the CUBN gene.[5][6][7] It is present upon the luminal surface of enterocytes of the ileum where it facilitates absorption of vitamin B12 by acting as a receptor for IF-cobalamin (intrinsic factor - vitamin B12) complexes, enabling endocytosis of complexes by means of amnionless (AMN).[8][9]
Biochemistry
Cubilinis essentially only present in the small intestine and kidneys.[10]
A complex of amnionless and cubilin forms the cubam receptor.[11]
Clinical significance
Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.[7]
Cubilin is a potential diagnostic and prognostic cancer biomarker for kidney cancer.[12] Based on patient survival data, high levels of cubilin in tumor cells is a favourable prognostic biomarker in renal cell carcinoma.[13][14]
