Cubilin

CUBN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KQ4
Identifiers
Aliases	CUBN, IFCR, MGA1, gp280, cubilin, IGS, IGS1
External IDs	OMIM: 602997; MGI: 1931256; HomoloGene: 37434; GeneCards: CUBN; OMA:CUBN - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,129,811 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	13,496,624 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; glomerulus; ; renal medulla; ; metanephric glomerulus; ; sperm; ; oocyte; ; right uterine tube; ; human kidney; ; gonad; ; secondary oocyte;
	Top expressed in
	primitive streak; ; yolk sac; ; ileum; ; human kidney; ; epithelium of small intestine; ; intestinal villus; ; jejunum; ; epithelium of lens; ; Ileal epithelium; ; right kidney;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; protein binding; transporter activity; cobalamin binding; metal ion binding; channel regulator activity; hemoglobin binding; signaling receptor activity; cargo receptor activity;
Cellular component	brush border; extrinsic component of external side of plasma membrane; endoplasmic reticulum; clathrin-coated pit; lysosomal membrane; cytoplasm; Golgi apparatus; endosome; apical part of cell; lysosome; lysosomal lumen; membrane; cytosol; extracellular exosome; endocytic vesicle; endosome membrane; plasma membrane; apical plasma membrane; brush border membrane; Golgi-associated vesicle; ionotropic glutamate receptor complex; coated vesicle; endocytic vesicle membrane; neuron projection membrane; synapse;
Biological process	tissue homeostasis; cobalamin transport; lipid metabolism; protein transport; cholesterol metabolic process; vitamin D metabolic process; cobalamin metabolic process; steroid metabolic process; endocytosis; lipoprotein transport; receptor-mediated endocytosis; high-density lipoprotein particle clearance; transport; in utero embryonic development; thigmotaxis; hyperosmotic response; response to nutrient; adult locomotory behavior; response to bacterium; endocytic hemoglobin import into cell; regulation of locomotion; cobalamin catabolic process; positive regulation of synaptic transmission, glutamatergic; protein homotrimerization;
	Sources:Amigo / QuickGO
Orthologs
	8029
	65969
	ENSG00000107611
	ENSMUSG00000026726
	O60494
	Q9JLB4
	NM_001081
	NM_001081084
	NP_001072
	NP_001074553
	Wikidata
View/Edit Human	View/Edit Mouse

Cubilin is a protein that in humans is encoded by the CUBN gene.^[5]^[6]^[7] It is present upon the luminal surface of enterocytes of the ileum where it facilitates absorption of vitamin B12 by acting as a receptor for IF-cobalamin (intrinsic factor - vitamin B12) complexes, enabling endocytosis of complexes by means of amnionless (AMN).^[8]^[9]