GJA4

GJA4
Identifiers
Aliases	GJA4, CX37, gap junction protein alpha 4
External IDs	OMIM: 121012; MGI: 95715; HomoloGene: 1556; GeneCards: GJA4; OMA:GJA4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	34,795,747 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	127,207,832 bp
RNA expression pattern
	Top expressed in
	tibial arteries; ; apex of heart; ; right lung; ; vena cava; ; left ventricle; ; left coronary artery; ; right lobe of thyroid gland; ; right coronary artery; ; subcutaneous adipose tissue; ; right ventricle;
	Top expressed in
	primary oocyte; ; morula; ; external carotid artery; ; internal carotid artery; ; secondary oocyte; ; zygote; ; right lung; ; right lung lobe; ; left lung; ; ankle joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; gap junction; cell junction; plasma membrane; integral component of plasma membrane; connexin complex; membrane;
Biological process	cell communication; cell-cell signaling; blood vessel development; response to pain; calcium ion transport; cell-cell junction assembly; endothelium development;
	Sources:Amigo / QuickGO
Orthologs
	2701
	14612
	ENSG00000187513
	ENSMUSG00000050234
	P35212
	P28235
	NM_002060
	NM_008120
	NP_002051
	NP_032146
	Wikidata
View/Edit Human	View/Edit Mouse

Gap junction alpha-4 protein, also known as Connexin-37 or Cx37, is a protein that in humans is encoded by the GJA4 gene.^[5]^[6]^[7] This protein, like other Connexin proteins, forms connections between cells known as gap junctions. Connexin 37 can be found in many tissues including the ovary,^[8] heart,^[9] and kidney.^[10]