CyRL-QN15

Pharmaceutical compound From Wikipedia, the free encyclopedia

CyRL-QN15 is a cyclic heptapeptide derivative with the sequence CQFHYMC, linked by a disulphide bond between the two cysteine residues. It was derived from peptides found in the skin secretions of the frog Rana limnocharis.[1][2] It enhances wound healing and has been researched for the treatment of diabetic ulcers. It has several different mechanisms of action, including acting as an antagonist at TLR4 and indirectly activating SIRT1.[3][4][5][6][7][8][9][10]

FormulaC40H52N10O10S3
Molar mass929.10 g·mol−1
3D model (JSmol)
Quick facts Chemical and physical data, Formula ...
CyRL-QN15
Chemical and physical data
FormulaC40H52N10O10S3
Molar mass929.10 g·mol−1
3D model (JSmol)
  • O=C(O)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CSSC1)CCC(=O)N)Cc1ccccc1)Cc1[NH]cnc1)Cc1ccc(O)cc1)CCSC
  • InChI=InChI=1S/C40H52N10O10S3/c1-61-14-13-28-36(55)50-32(40(59)60)20-63-62-19-26(41)34(53)45-27(11-12-33(42)52)35(54)47-29(15-22-5-3-2-4-6-22)38(57)49-31(17-24-18-43-21-44-24)39(58)48-30(37(56)46-28)16-23-7-9-25(51)10-8-23/h2-10,18,21,26-32,51H,11-17,19-20,41H2,1H3,(H2,42,52)(H,43,44)(H,45,53)(H,46,56)(H,47,54)(H,48,58)(H,49,57)(H,50,55)(H,59,60)/t26-,27-,28-,29-,30-,31-,32-/m0/s1
  • Key:CDGOXQBMPZQUIZ-YYGRSCHNSA-N
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