DACH2

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Dachshund homolog 2 is a protein that in humans is encoded by the DACH2 gene.[5]

AliasesDACH2, dachshund family transcription factor 2
End86,832,604 bp[1]
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DACH2
Identifiers
AliasesDACH2, dachshund family transcription factor 2
External IDsOMIM: 300608; MGI: 1890446; HomoloGene: 33472; GeneCards: DACH2; OMA:DACH2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001139514
NM_001139515
NM_053281

NM_001142570
NM_001289732
NM_001289733
NM_001289734
NM_033605

RefSeq (protein)

NP_001132986
NP_001132987
NP_444511

NP_001136042
NP_001276661
NP_001276662
NP_001276663
NP_291083

Location (UCSC)Chr X: 86.15 – 86.83 MbChr X: 112.21 – 112.75 Mb
PubMed search[3][4]
Wikidata
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Function

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in the regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.

References

Further reading

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