DAPK1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.[5]
Function
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.[6]
In melanocytic cells DAPK1 gene expression may be regulated by MITF.[7]
As a drug target
Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers.[8] This has not been demonstrated in actual patients.
