DCP1B

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.^[5][6][7]

AliasesDCP1B, DCP1, hDcp1b, decapping mRNA 1B

External IDsOMIM: 609843; MGI: 2442404; HomoloGene: 51881; GeneCards: DCP1B; OMA:DCP1B - orthologs

Chr.Chromosome 12 (human)^[1]

End2,004,535 bp^[1]

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DCP1B
Identifiers
Aliases	DCP1B, DCP1, hDcp1b, decapping mRNA 1B
External IDs	OMIM: 609843; MGI: 2442404; HomoloGene: 51881; GeneCards: DCP1B; OMA:DCP1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.33 Start 1,946,053 bp[1] End 2,004,535 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F1 Start 119,175,253 bp[2] End 119,221,616 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon smooth muscle tissue body of uterus gonad myometrium right adrenal gland right adrenal cortex popliteal artery tibial arteries left adrenal gland Top expressed in seminiferous tubule superior cervical ganglion spermatocyte spermatid otolith organ utricle Rostral migratory stream genital tubercle spinal ganglia tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme regulator activity enzyme activator activity protein binding mRNA binding hydrolase activity Cellular component P-body membrane intracellular membrane-bounded organelle nucleus cytoplasm cytosol Biological process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay positive regulation of catalytic activity deadenylation-independent decapping of nuclear-transcribed mRNA deadenylation-dependent decapping of nuclear-transcribed mRNA exonucleolytic catabolism of deadenylated mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 196513 319618 Ensembl ENSG00000151065 ENSG00000284850 ENSMUSG00000041477 UniProt Q8IZD4 B9EIX0 RefSeq (mRNA) NM_152640 NM_001319292 NM_001033379 RefSeq (protein) NP_001306221 NP_689853 NP_001028551 Location (UCSC) Chr 12: 1.95 – 2 Mb Chr 6: 119.18 – 119.22 Mb PubMed search [3] [4]
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DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM]^[7]