DDEF1

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ASAP1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesASAP1, AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

External IDsOMIM: 605953; MGI: 1342335; HomoloGene: 7684; GeneCards: ASAP1; OMA:ASAP1 - orthologs

Chr.Chromosome 8 (human)^[1]

Quick facts ASAP1, Available structures ...

ASAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D1X, 2DA0, 2ED1, 2RQT, 2RQU
Identifiers
Aliases	ASAP1, AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
External IDs	OMIM: 605953; MGI: 1342335; HomoloGene: 7684; GeneCards: ASAP1; OMA:ASAP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.21-q24.22 Start 130,052,104 bp[1] End 130,443,674 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 63,958,706 bp[2] End 64,254,768 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell sural nerve trabecular bone sperm Achilles tendon lateral nuclear group of thalamus oocyte secondary oocyte visceral pleura Brodmann area 23 Top expressed in saccule tail of embryo genital tubercle otic placode otic vesicle granulocyte secondary oocyte Rostral migratory stream zygote lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-4,5-bisphosphate binding protein binding phosphatidylinositol-3,4,5-trisphosphate binding metal ion binding GTPase activator activity phosphatidylserine binding cadherin binding Cellular component cytoplasm cytosol dendritic spine membrane podosome cell projection membrane plasma membrane Biological process cilium assembly positive regulation of GTPase activity negative regulation of dendritic spine development cell projection organization positive regulation of podosome assembly positive regulation of membrane tubulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50807 13196 Ensembl ENSG00000153317 ENSMUSG00000022377 UniProt Q9ULH1 Q9QWY8 RefSeq (mRNA) NM_001247996 NM_018482 NM_001362925 NM_001362926 NM_001362924 NM_001276461 NM_001276462 NM_001276463 NM_001276467 NM_010026 RefSeq (protein) NP_001234925 NP_060952 NP_001349854 NP_001349855 NP_001349853 NP_001263390 NP_001263391 NP_001263392 NP_001263396 NP_034156 Location (UCSC) Chr 8: 130.05 – 130.44 Mb Chr 15: 63.96 – 64.25 Mb PubMed search [3] [4]
Wikidata
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