DIS3L

DIS3L
Identifiers
Aliases	DIS3L, DIS3L1, DIS3 like exosome 3'-5' exoribonuclease
External IDs	OMIM: 614183; MGI: 2143272; HomoloGene: 15797; GeneCards: DIS3L; OMA:DIS3L - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	66,333,898 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	64,248,570 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; corpus callosum; ; tibialis anterior muscle; ; deltoid muscle; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; Achilles tendon; ; skin of arm; ; gonad;
	Top expressed in
	spermatocyte; ; spermatid; ; secondary oocyte; ; seminiferous tubule; ; primary oocyte; ; muscle of thigh; ; zygote; ; interventricular septum; ; right kidney; ; hand;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; nuclease activity; exonuclease activity; protein binding; hydrolase activity; RNA binding; 3'-5'-exoribonuclease activity; endonuclease activity; ribonuclease activity;
Cellular component	cytoplasmic exosome (RNase complex); centrosome; plasma membrane; exosome (RNase complex); cytoplasm; cytosol; nuclear exosome (RNase complex);
Biological process	rRNA processing; RNA phosphodiester bond hydrolysis, exonucleolytic; rRNA catabolic process; RNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	115752
	213550
	ENSG00000166938
	ENSMUSG00000032396
	Q8TF46
	Q8C0S1
NM_001143688; NM_133375; NM_001323936; NM_001323937; NM_001323938;
	NM_001323939; NM_001323940; NM_001323941; NM_001323943; NM_001323944; NM_001323945; NM_001323946; NM_001323948
	NM_001001295; NM_001177784; NM_172519
NP_001137160; NP_001310865; NP_001310866; NP_001310867; NP_001310868;
	NP_001310869; NP_001310870; NP_001310872; NP_001310873; NP_001310874; NP_001310875; NP_001310877; NP_588616
	NP_001001295; NP_001171255; NP_766107
	Wikidata
View/Edit Human	View/Edit Mouse

DIS3-like exonuclease 1 (Dis3L1 or Dis3L) is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.^[5]^[6]