DIS3L2

DIS3L2
Identifiers
Aliases	DIS3L2, FAM6A, PRLMNS, hDIS3 like 3'-5' exoribonuclease 2
External IDs	OMIM: 614184; MGI: 2442555; HomoloGene: 62417; GeneCards: DIS3L2; OMA:DIS3L2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,344,350 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	86,977,817 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; sperm; ; buccal mucosa cell; ; right uterine tube; ; right lobe of thyroid gland; ; right testis; ; left testis; ; Achilles tendon; ; left lobe of thyroid gland; ; left ovary;
	Top expressed in
	spermatid; ; Rostral migratory stream; ; hand; ; spermatocyte; ; lumbar spinal ganglion; ; lens; ; muscle of thigh; ; genital tubercle; ; lumbar subsegment of spinal cord; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	3'-5'-exoribonuclease activity; poly(U) RNA binding; metal ion binding; ribonuclease activity; protein binding; RNA binding; nuclease activity; exonuclease activity; hydrolase activity; magnesium ion binding;
Cellular component	cytoplasm; polysome; P-body; exosome (RNase complex);
Biological process	miRNA catabolic process; nucleic acid phosphodiester bond hydrolysis; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; cell division; stem cell population maintenance; rRNA processing; cell cycle; mitotic sister chromatid separation; negative regulation of cell population proliferation; RNA phosphodiester bond hydrolysis, exonucleolytic; RNA phosphodiester bond hydrolysis; nuclear-transcribed mRNA catabolic process, exonucleolytic; polyuridylation-dependent mRNA catabolic process; mitotic cell cycle; RNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	129563
	208718
	ENSG00000144535
	ENSMUSG00000053333
	Q8IYB7
	Q8CI75
	NM_001257281; NM_001257282; NM_152383
	NM_001172157; NM_153530
	NP_001244210; NP_001244211; NP_689596
	NP_001165628; NP_705758
	Wikidata
View/Edit Human	View/Edit Mouse

DIS3 mitotic control homolog (S. cerevisiae)-like 2 is a protein in humans that is encoded by the DIS3L2 gene.^[5] The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012].