DKK2

Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesDKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2

External IDsOMIM: 605415; MGI: 1890663; HomoloGene: 8681; GeneCards: DKK2; OMA:DKK2 - orthologs

Chr.Chromosome 4 (human)^[1]

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DKK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JTK
Identifiers
Aliases	DKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2
External IDs	OMIM: 605415; MGI: 1890663; HomoloGene: 8681; GeneCards: DKK2; OMA:DKK2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 106,921,802 bp[1] End 107,283,806 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 131,791,053 bp[2] End 131,886,065 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip buccal mucosa cell Achilles tendon testicle Skeletal muscle tissue of rectus abdominis hair follicle thoracic diaphragm right lung muscle of thigh Top expressed in vestibular membrane of cochlear duct external carotid artery internal carotid artery iris glomerulus umbilical cord conjunctival fornix saccule gastrula glomerular mesangium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function co-receptor binding receptor antagonist activity Cellular component extracellular region extracellular space Biological process positive regulation of canonical Wnt signaling pathway multicellular organism development negative regulation of Wnt signaling pathway Wnt signaling pathway negative regulation of canonical Wnt signaling pathway extracellular negative regulation of signal transduction negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27123 56811 Ensembl ENSG00000155011 ENSMUSG00000028031 UniProt Q9UBU2 Q9QYZ8 RefSeq (mRNA) NM_014421 NM_020265 RefSeq (protein) NP_055236 NP_064661 Location (UCSC) Chr 4: 106.92 – 107.28 Mb Chr 3: 131.79 – 131.89 Mb PubMed search [3] [4]
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This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.

It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).^[6]