Dedicator of cytokinesis protein 6
Protein found in humans
From Wikipedia, the free encyclopedia
Dedicator of cytokinesis protein 6 (Dock6), also known as Zir1 is a large (~200 kDa) protein encoded in the human by the DOCK6 gene, involved in intracellular signalling networks.[5] It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G-proteins.
| DOCK6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | DOCK6, AOS2, ZIR1, Dock6, dedicator of cytokinesis 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614194; MGI: 1914789; HomoloGene: 83291; GeneCards: DOCK6; OMA:DOCK6 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Discovery
Dock6 was identified as one of a family of proteins which share high sequence similarity with Dock180, the archetypal member of the DOCK family.[6] It has a similar domain arrangement to other DOCK proteins,[7] with a DHR1 domain known in other proteins to bind phospholipids,[8] and a DHR2 domain containing the GEF activity.[9]
Function
There is currently very little information about the cellular role of this protein. However, Dock6 has been reported to exhibit dual GEF specificity towards the small G proteins Rac1 and Cdc42.[10] It is the only DOCK family member reported to activate both of these G proteins. The same study also showed that transfection of the Dock6 DHR2 domain into N1E-115 neuroblastoma cells promoted Rac- and Cdc42-dependent neurite outgrowth, although the physiological significance of this has yet to be demonstrated.
