DOK2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesDOK2, p56DOK, p56dok-2, docking protein 2
Quick facts Available structures, PDB ...
DOK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDOK2, p56DOK, p56dok-2, docking protein 2
External IDsOMIM: 604997; MGI: 1332623; HomoloGene: 2957; GeneCards: DOK2; OMA:DOK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003974
NM_201349
NM_001317800
NM_001401272

NM_010071

RefSeq (protein)

NP_001304729
NP_003965
NP_958728

NP_034201
NP_001388209
NP_001388210

Location (UCSC)Chr 8: 21.91 – 21.91 MbChr 14: 70.77 – 70.78 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.[7]

Interactions

DOK2 has been shown to interact with INPP5D[8] and TEK tyrosine kinase.[9][10]

References

Further reading

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