DOK5

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesDOK5, C20orf180, IRS-6, IRS6, docking protein 5
Quick facts Available structures, PDB ...
DOK5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDsOMIM: 608334; MGI: 1924079; HomoloGene: 10195; GeneCards: DOK5; OMA:DOK5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001294161
NM_018431
NM_177959

NM_001163686
NM_029761

RefSeq (protein)

NP_001281090
NP_060901
NP_808874

NP_001157158
NP_084037

Location (UCSC)Chr 20: 54.48 – 54.65 MbChr 2: 170.57 – 170.72 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[6]

Interactions

DOK5 has been shown to interact with RET proto-oncogene.[5][7]

References

Further reading

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