DPM1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Dolichol-phosphate mannosyltransferase is an enzyme that in humans is encoded by the DPM1 gene.[5][6][7]
AliasesDPM1, CDGIE, MPDS, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, dolichyl-phosphate mannosyltransferase subunit 1, catalytic
External IDsOMIM: 603503; MGI: 1330239; HomoloGene: 2865; GeneCards: DPM1; OMA:DPM1 - orthologs
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| Aliases | DPM1, CDGIE, MPDS, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, dolichyl-phosphate mannosyltransferase subunit 1, catalytic | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 603503; MGI: 1330239; HomoloGene: 2865; GeneCards: DPM1; OMA:DPM1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.[7]
