DPP7

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesDPP7, DPP2, DPPII, QPP, dipeptidyl peptidase 7

External IDsOMIM: 610537; MGI: 1933213; HomoloGene: 22748; GeneCards: DPP7; OMA:DPP7 - orthologs

Chr.Chromosome 9 (human)^[1]

Quick facts Available structures, PDB ...

DPP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JYH, 3N0T, 4EBB
Identifiers
Aliases	DPP7, DPP2, DPPII, QPP, dipeptidyl peptidase 7
External IDs	OMIM: 610537; MGI: 1933213; HomoloGene: 22748; GeneCards: DPP7; OMA:DPP7 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,110,546 bp[1] End 137,115,177 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,242,288 bp[2] End 25,246,371 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right hemisphere of cerebellum right uterine tube granulocyte right lobe of thyroid gland left testis apex of heart right testis left lobe of thyroid gland right frontal lobe Top expressed in choroid plexus of fourth ventricle yolk sac right kidney epithelium of small intestine calvaria proximal tubule human kidney decidua Epithelium of choroid plexus iris More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity hydrolase activity aminopeptidase activity serine-type peptidase activity dipeptidyl-peptidase activity Cellular component cytosol Golgi apparatus lysosome cytoplasmic vesicle vesicle intracellular membrane-bounded organelle extracellular exosome extracellular region azurophil granule lumen Biological process neutrophil degranulation proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29952 83768 Ensembl ENSG00000176978 ENSMUSG00000026958 UniProt Q9UHL4 Q9ET22 RefSeq (mRNA) NM_013379 NM_031843 RefSeq (protein) NP_037511 NP_114031 Location (UCSC) Chr 9: 137.11 – 137.12 Mb Chr 2: 25.24 – 25.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH.^[7]