DYNLRB1

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesDYNLRB1, BITH, BLP, DNCL2A, DNLC2A, ROBLD1, dynein light chain roadblock-type 1

External IDsOMIM: 607167; MGI: 1914318; HomoloGene: 69161; GeneCards: DYNLRB1; OMA:DYNLRB1 - orthologs

Chr.Chromosome 20 (human)^[1]

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DYNLRB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z09, 2B95, 2E8J, 2HZ5
Identifiers
Aliases	DYNLRB1, BITH, BLP, DNCL2A, DNLC2A, ROBLD1, dynein light chain roadblock-type 1
External IDs	OMIM: 607167; MGI: 1914318; HomoloGene: 69161; GeneCards: DYNLRB1; OMA:DYNLRB1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 34,516,409 bp[1] End 34,540,958 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,078,453 bp[2] End 155,092,197 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 right frontal lobe anterior cingulate cortex right hemisphere of cerebellum tibial nerve C1 segment islet of Langerhans left coronary artery popliteal artery tibial arteries Top expressed in genital tubercle supraoptic nucleus tail of embryo neural layer of retina seminal vesicula yolk sac dentate gyrus of hippocampal formation granule cell ascending aorta aortic valve ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding microtubule motor activity cytoskeletal motor activity dynein intermediate chain binding Cellular component centrosome ciliary tip cytoskeleton membrane cytoplasm microtubule cilium cytoplasmic dynein complex dynein complex outer dynein arm Biological process visual behavior microtubule-based movement intraciliary transport involved in cilium assembly transport response to light stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83658 67068 Ensembl ENSG00000125971 ENSMUSG00000047459 UniProt Q9NP97 P62627 RefSeq (mRNA) NM_001281727 NM_001281728 NM_001281729 NM_014183 NM_177953 NM_001319157 NM_001291108 NM_025947 RefSeq (protein) NP_001306086 NP_054902 NP_001369294 NP_001369295 NP_001369296 NP_001278037 NP_080223 Location (UCSC) Chr 20: 34.52 – 34.54 Mb Chr 2: 155.08 – 155.09 Mb PubMed search [3] [4]
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This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.^[7]