DYNLT1

DYNLT1
Identifiers
Aliases	DYNLT1, CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1
External IDs	OMIM: 601554; MGI: 98643; HomoloGene: 4754; GeneCards: DYNLT1; OMA:DYNLT1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	158,644,743 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	6,703,695 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; epithelium of nasopharynx; ; olfactory zone of nasal mucosa; ; palpebral conjunctiva; ; nasal epithelium; ; oral cavity; ; ganglionic eminence; ; islet of Langerhans; ; jejunal mucosa; ; mucosa of paranasal sinus;
	Top expressed in
	spermatid; ; spermatocyte; ; neural tube; ; mesencephalon; ; lens; ; testicle; ; islet of Langerhans; ; granulocyte; ; epiblast; ; urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; cytoskeletal motor activity; protein C-terminus binding;
Cellular component	cytoplasm; Golgi apparatus; secretory vesicle; spindle; dynein complex; cytoplasmic microtubule; microtubule; cytoskeleton; host cell; extracellular region; cytoplasmic dynein complex; secretory granule lumen; ficolin-1-rich granule lumen; mitochondrion; lamellipodium; soma; axonal growth cone;
Biological process	intracellular transport of viral protein in host cell; regulation of G protein-coupled receptor signaling pathway; negative regulation of neurogenesis; nervous system development; cell division; establishment of mitotic spindle orientation; microtubule-dependent intracellular transport of viral material towards nucleus; viral entry into host cell; cell cycle; viral process; transport of viral material towards nucleus; neutrophil degranulation; positive regulation of neuron projection development; dendrite development; positive regulation of Rac protein signal transduction; negative regulation of mitochondrial membrane permeability; regulation of GTPase activity; neuron projection morphogenesis; regulation of cytoskeleton organization; negative regulation of cell death; axon development;
	Sources:Amigo / QuickGO
Orthologs
	6993
	21648
	ENSG00000146425
	ENSMUSG00000096255
	P63172
	P51807
	NM_006519; NM_001291602; NM_001291603
	NM_009342
	NP_001278531; NP_001278532; NP_006510
	NP_001160099; NP_001186877; NP_001160102; NP_001160101; NP_033368
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.^[5]^[6]^[7]

AliasesDYNLT1, CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1

External IDsOMIM: 601554; MGI: 98643; HomoloGene: 4754; GeneCards: DYNLT1; OMA:DYNLT1 - orthologs

Chr.Chromosome 6 (human)^[1]

End158,644,743 bp^[1]

Quick facts Identifiers, Aliases ...

Close

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]^[7]

In cancer patients, DYNLT1 expression has been linked to both higher and lower survival rates, depending on cancer type.^[8]

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

DYNLT1

References

Further reading

Related Articles

Related Articles

"Cytoplasmic dynein nomenclature"

"Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome"

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"

"The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth"

"Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin"