DYRK2

Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme, in particular a dual-specificity kinase, that in humans is encoded by the DYRK2 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesDYRK2, dual specificity tyrosine phosphorylation regulated kinase 2

External IDsOMIM: 603496; MGI: 1330301; HomoloGene: 48437; GeneCards: DYRK2; OMA:DYRK2 - orthologs

Chr.Chromosome 12 (human)^[1]

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DYRK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3K2L, 3KVW, 4AZF
Identifiers
Aliases	DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
External IDs	OMIM: 603496; MGI: 1330301; HomoloGene: 48437; GeneCards: DYRK2; OMA:DYRK2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 67,648,338 bp[1] End 67,665,406 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 118,691,508 bp[2] End 118,706,114 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon Skeletal muscle tissue of rectus abdominis vastus lateralis muscle pylorus biceps brachii Skeletal muscle tissue of biceps brachii visceral pleura right ventricle hair follicle Top expressed in otolith organ utricle epithelium of lens hand knee joint retinal pigment epithelium left colon hair follicle digastric muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity manganese ion binding kinase activity protein binding protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity ATP binding magnesium ion binding protein serine/threonine kinase activity Cellular component cytoplasm ubiquitin ligase complex nucleus nucleoplasm cytosol ribonucleoprotein complex Biological process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of glycogen biosynthetic process phosphorylation cellular response to DNA damage stimulus protein phosphorylation smoothened signaling pathway apoptotic process regulation of signal transduction by p53 class mediator peptidyl-tyrosine phosphorylation negative regulation of calcineurin-NFAT signaling cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8445 69181 Ensembl ENSG00000127334 ENSMUSG00000028630 UniProt Q92630 Q5U4C9 RefSeq (mRNA) NM_006482 NM_003583 NM_001014390 RefSeq (protein) NP_003574 NP_006473 NP_001014412 Location (UCSC) Chr 12: 67.65 – 67.67 Mb Chr 10: 118.69 – 118.71 Mb PubMed search [3] [4]
Wikidata
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DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.^[6]