Daniel Trachsel
Swiss chemist
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Daniel Trachsel is a Swiss chemist who studies psychedelics and entactogens.[1][2] He has developed and published on a large number of novel psychedelic and entactogen compounds, including their psychoactive effects.[1][2][3] This has been in a manner similar to that of the psychedelic chemist Alexander Shulgin, which has caused Trachsel to sometimes be referred to as the "German Shulgin".[1][2] However, unlike Shulgin, Trachsel has distanced himself from any personal self-experiments.[1]
Yearsactive1993–present
OrganizationReseaChem
Notable workPsychedelische Chemie Aspekte Psychoaktiver Moleküle (2000); Phenethylamine: von der Struktur zur Funktion (2013)
Daniel Trachsel | |
|---|---|
| Alma mater | Burgdorf University of Applied Sciences |
| Years active | 1993–present |
| Organization | ReseaChem |
| Notable work | Psychedelische Chemie Aspekte Psychoaktiver Moleküle (2000); Phenethylamine: von der Struktur zur Funktion (2013) |
| Website | https://nachtschatten.ch/autoren/trachsel/ |
According to Hamilton Morris and Nick Cozzi in mid-2023, Trachel's book Phenethylamine: von der Struktur zur Funktion (Phenethylamines: From Structure to Function) is in the process of being translated into English.[4] It is being translated by the Alexander Shulgin Research Institute (ASRI), with tentative publication by Transform Press, and also independently by chemist David Carlson.[4]
Compounds
Compounds that were first synthesized, tested in humans, and/or reported by Trachsel and colleagues include:[5]
- 2Cs
- DOx
- 4Cs
- Scalines
- 2-Methylmescaline
- 2,6-Dimethylmescaline
- Cycloproscaline (CP)
- Difluoroescaline (DFE)
- Difluoromescaline (DFM)
- Fluoroescaline (FE)
- Fluoroproscaline (FP)
- Isobuscaline (IB)
- Metadifluoromescaline (MDFM)
- Phescaline
- Tomscaline
- Trifluoroescaline (TFE)
- Trifluoromescaline (TFM)
- Trifluoroproscaline (TFP)
- 3Cs
- ψ-Phenethylamines
- 2,4,6-TMPEA (ψ-2C-O)
- ψ-2C-DFMO
- ψ-DODFMO
- BOx and related
- N-Benzylphenethylamines
- MDxx
- 3C-BOH
- 6-Chloro-MDA
- 6-Methyl-MDA
- DFMDA (F2-MDA)
- DFMDMA (F2-MDMA)
- Lysergamides
Selected publications
Books
- Trachsel, D.; Richard, N. (2000). Psychedelische Chemie Aspekte Psychoaktiver Moleküle [Psychedelic Chemistry: Aspects of Psychoactive Molecules] (in German) (1 ed.). Nachtschatten-Verlag. ISBN 978-3-907080-53-5. OCLC 247657972. Archived from the original on 18 October 2025. [Note: There are also several subsequent editions (2nd (2002) through 5th (2016)).][6]
- Trachsel, D.; Lehmann, D.; Enzensperger, C. (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
Papers
- Trachsel, Daniel (2002). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate" [Synthesis of new (phenylalkyl)amines for the investigation of structure-activity relationships, Communication 1, Mescaline derivatives] (PDF). Helvetica Chimica Acta. 85 (9): 3019–3026. doi:10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4.
- Trachsel, Daniel (2003). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2: 4-Thio-substituierte [2-(2,5-Dimethoxyphenyl)ethyl]amine (=2,5-Dimethoxybenzolethanamine)" [Synthesis of new (phenylalkyl)amines for the investigation of structure–activity relationships. Communication 2: 4-thio-substituted [2-(2,5-dimethoxyphenyl)ethyl]amines (=2,5-dimethoxybenzenethanamines)]. Helvetica Chimica Acta. 86 (7): 2610–2619. doi:10.1002/hlca.200390210. ISSN 0018-019X.
- Trachsel, Daniel (2003). "Synthesis of Novel (Phenylalkyl)amines for the Investigation of Structure–Activity Relationships, Part 3: 4-Ethynyl-2,5-dimethoxyphenethylamine (=4-Ethynyl-2,5-dimethoxybenzeneethanamine; 2C-YN)". Helvetica Chimica Acta. 86 (8): 2754–2759. doi:10.1002/hlca.200390224. ISSN 0018-019X.
- Trachsel D, Hadorn M, Baumberger F (March 2006). "Synthesis of fluoro analogues of 3,4-(methylenedioxy)amphetamine (MDA) and its derivatives". Chem Biodivers. 3 (3): 326–336. doi:10.1002/cbdv.200690035. PMID 17193269.
- Trachsel D, Nichols DE, Kidd S, Hadorn M, Baumberger F (May 2009). "4-aryl-substituted 2,5-dimethoxyphenethylamines: synthesis and serotonin 5-HT(2A) receptor affinities". Chem Biodivers. 6 (5): 692–704. doi:10.1002/cbdv.200800235. PMID 19479848.
- Trachsel D (2012). "Fluorine in psychedelic phenethylamines". Drug Test Anal. 4 (7–8): 577–590. doi:10.1002/dta.413. PMID 22374819.
- Luethi D, Trachsel D, Hoener MC, Liechti ME (May 2018). "Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)" (PDF). Neuropharmacology. 134 (Pt A): 141–148. doi:10.1016/j.neuropharm.2017.07.012. PMID 28720478.
- Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME (2021). "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines" (PDF). Front Pharmacol. 12 794254. doi:10.3389/fphar.2021.794254. PMC 8865417. PMID 35222010.
- Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME (January 2023). "Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines" (PDF). Psychopharmacology (Berl). 240 (1): 115–126. doi:10.1007/s00213-022-06279-2. PMC 9816194. PMID 36477925.
- Kolaczynska, Karolina E.; Trachsel, Daniel; Hoener, Marius C.; Liechti, Matthias E.; Luethi, Dino (20 November 2025). "Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines". Frontiers in Pharmacology. 16. doi:10.3389/fphar.2025.1703480. ISSN 1663-9812.