Dilazep

Chemical compound From Wikipedia, the free encyclopedia

Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor.[1][2]

Trade namesComelian Kowa
AHFS/Drugs.comInternational Drug Names
ATC code
CAS Number
Quick facts Clinical data, Trade names ...
Dilazep
Clinical data
Trade namesComelian Kowa
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 3-(4-{3-[(3,4,5-Trimethoxyphenyl)carbonyloxy]propyl}-1,4-diazepan-1-yl)propyl 3,4,5-trimethoxybenzoate
CAS Number
PubChem CID
IUPHAR/BPS
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KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC31H44N2O10
Molar mass604.697 g·mol−1
3D model (JSmol)
  • O=C(OCCCN2CCCN(CCCOC(=O)c1cc(OC)c(OC)c(OC)c1)CC2)c3cc(OC)c(OC)c(OC)c3
  • InChI=1S/C31H44N2O10/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4/h18-21H,7-17H2,1-6H3 checkY
  • Key:QVZCXCJXTMIDME-UHFFFAOYSA-N checkY
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It is used for the treatment of cardiopathy and renal disorders.[3]

Synthesis

The reaction of bis(3-hydroxypropyl)ethylene diamine (1) with 1-bromo-3-chloropropane (2) gives the homopiperazine derivative 3. Esterification by reaction with 3,4,5-trimethoxybenzoyl chloride (4) completes the synthesis of dilazep (5).[4][5][6]

Synthesis of dilazep

See also

References

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