Dimetacrine

Dimetacrine (also known as dimethacrine and acripramine; brand names Istonil, Istonyl, Linostil, and Miroistonil) is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.^{[2][3][4][5][6]} It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.^[7][8]

Trade namesIstonil, Istonyl, Linostil, Miroistonil

Other namesDimethacrine, acripramine

Routes of
administrationOral

ATC code

• N06AA18 (WHO)

Quick facts Clinical data, Trade names ...

Dimetacrine

Clinical data
Trade names	Istonil, Istonyl, Linostil, Miroistonil
Other names	Dimethacrine, acripramine
Routes of administration	Oral
ATC code	N06AA18 (WHO)
Legal status
Legal status	BR: Class C1 (Other controlled substances)[1] In general: ℞ (Prescription only)
Identifiers
IUPAC name 3-(9,9-Dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
CAS Number	4757-55-5
PubChem CID	94280
DrugBank	DB08996 Y
ChemSpider	85085
UNII	O341NY501N
KEGG	D02565
CompTox Dashboard (EPA)	DTXSID4022941
Chemical and physical data
Formula	C20H26N2
Molar mass	294.442 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C

Close

Little is known about the pharmacology of dimetacrine,^[9] but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).