E2F1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.[5]
Function
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.[6]
Transcription
E2F1 promoter[PAX8] => E2F1[7]
Interactions
E2F1 has been shown to interact with:
- ARID3A,[8]
- CUL1,[9]
- Cyclin A1,[10]
- Cyclin A2,[11]
- GTF2H1,[12]
- MDM4,[13]
- NCOA6,[14]
- NDN,[15][16]
- NPDC1,[17]
- PURA,[18]
- PHB,[19][20][21][22]
- RB1,[15][23][24][25][26][27][28]
- UDG,[29]
- RBL1,[23]
- SKP2,[9]
- SP1,[30][31][32]
- SP2,[30]
- SP3,[30]
- SP4,[30]
- TFDP1[8][28][33][34]
- TOPBP1,[35][36]
- TP53BP1,[26] and
- UBC.[37]