Evolutionary Classification of Protein Domains
From Wikipedia, the free encyclopedia
The Evolutionary Classification of Protein Domains (ECOD) is a biological database that classifies protein domains available from the Protein Data Bank. The ECOD tries to determine the evolutionary relationships between proteins.
Data types
capturedProtein domains
capturedProtein domains
AuthorsH. Cheng, R. D. Schaeffer, Y. Liao, L. N. Kinch, J. Pei, S. Shi, B. H. Kim, N. V. Grishin.
| Content | |
|---|---|
| Data types captured | Protein domains |
| Contact | |
| Research center | Grishin Lab, University of Texas Southwestern Medical Center |
| Authors | H. Cheng, R. D. Schaeffer, Y. Liao, L. N. Kinch, J. Pei, S. Shi, B. H. Kim, N. V. Grishin. |
| Primary citation | PMID 25474468 |
| Release date | 2014 |
| Access | |
| Website | http://prodata.swmed.edu/ecod/ |
| Miscellaneous | |
| Version | continuously updated |
| Curation policy | manual for new proteins; automated for ones with close matches |
Similar to Pfam, CATH, and SCOP, ECOD compiles domains instead of whole proteins. However, ECOD focuses on evolutionary relationships more heavily: instead of grouping proteins by folds, which may simply represent convergent evolution, ECOD groups proteins by demonstratable homology only.[1]
