EEF1A2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesEEF1A2, EEF1AL, EF-1-alpha-2, EF1A, HS1, STN, STNL, EIEE33, MRD38, eukaryotic translation elongation factor 1 alpha 2, DEE33
Quick facts Available structures, PDB ...
EEF1A2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEEF1A2, EEF1AL, EF-1-alpha-2, EF1A, HS1, STN, STNL, EIEE33, MRD38, eukaryotic translation elongation factor 1 alpha 2, DEE33
External IDsOMIM: 602959; MGI: 1096317; HomoloGene: 121568; GeneCards: EEF1A2; OMA:EEF1A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001958

NM_007906

RefSeq (protein)

NP_001949

NP_031932

Location (UCSC)Chr 20: 63.49 – 63.5 MbChr 2: 180.79 – 180.8 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas.

Clinical significance

This gene may be critical in the development of ovarian cancer.[7]

Regulation

EEF1A2 is a direct target of miRNA-663 and miRNA-744.[8]

References

Further reading

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