EGR3

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.^[5][6][7]

AliasesEGR3, EGR-3, PILOT, early growth response 3

External IDsOMIM: 602419; MGI: 1306780; HomoloGene: 37923; GeneCards: EGR3; OMA:EGR3 - orthologs

Chr.Chromosome 8 (human)^[1]

End22,693,480 bp^[1]

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EGR3
Identifiers
Aliases	EGR3, EGR-3, PILOT, early growth response 3
External IDs	OMIM: 602419; MGI: 1306780; HomoloGene: 37923; GeneCards: EGR3; OMA:EGR3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,687,659 bp[1] End 22,693,480 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D2 Start 70,314,652 bp[2] End 70,320,063 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh parietal pleura gastric mucosa mucosa of paranasal sinus lactiferous duct skin of arm sural nerve orbitofrontal cortex frontal pole periodontal fiber Top expressed in prefrontal cortex hair follicle primary motor cortex skin of abdomen olfactory tubercle skin of external ear cingulate gyrus nucleus accumbens piriform cortex temporal lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity metal ion binding DNA binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process circadian rhythm endothelial cell chemotaxis cell migration involved in sprouting angiogenesis muscle organ development regulation of transcription, DNA-templated positive regulation of endothelial cell proliferation cellular response to fibroblast growth factor stimulus negative regulation of apoptotic process cellular response to vascular endothelial growth factor stimulus transcription, DNA-templated neuromuscular synaptic transmission peripheral nervous system development positive regulation of T cell differentiation in thymus regulation of gamma-delta T cell differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cellular response to growth factor stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1960 13655 Ensembl ENSG00000179388 ENSMUSG00000033730 UniProt Q06889 P43300 RefSeq (mRNA) NM_001199880 NM_001199881 NM_004430 NM_001289925 NM_001289927 NM_018781 RefSeq (protein) NP_001186809 NP_001186810 NP_004421 NP_001276854 NP_001276856 NP_061251 Location (UCSC) Chr 8: 22.69 – 22.69 Mb Chr 14: 70.31 – 70.32 Mb PubMed search [3] [4]
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The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.^[7]