EI24

EI24
Identifiers
Aliases	EI24, EPG4, PIG8, TP53I8, autophagy associated transmembrane protein, EI24 autophagy associated transmembrane protein
External IDs	OMIM: 605170; MGI: 108090; HomoloGene: 3588; GeneCards: EI24; OMA:EI24 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	125,584,684 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	36,708,689 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right lobe of liver; ; body of pancreas; ; islet of Langerhans; ; rectum; ; gastrocnemius muscle; ; stromal cell of endometrium; ; muscle of thigh; ; mucosa of esophagus; ; skin of leg;
	Top expressed in
	transitional epithelium of urinary bladder; ; Ileal epithelium; ; medullary collecting duct; ; left lobe of liver; ; renal corpuscle; ; lacrimal gland; ; trigeminal ganglion; ; conjunctival fornix; ; medial ganglionic eminence; ; condyle;
	More reference expression data
	More reference expression data
Orthologs
	9538
	13663
	ENSG00000149547
	ENSMUSG00000062762
	O14681
	Q61070
	NM_001007277; NM_001290135; NM_004879; NM_001330419
	NM_001199494; NM_007915
	NP_001277064; NP_001317348; NP_004870
	NP_001186423; NP_031941
	Wikidata
View/Edit Human	View/Edit Mouse

Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.^[5]^[6]^[7]

AliasesEI24, EPG4, PIG8, TP53I8, autophagy associated transmembrane protein, EI24 autophagy associated transmembrane protein

End125,584,684 bp^[1]

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This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.^[7]

References