EIF1AY

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.^[5][6]

AliasesEIF1AY, eIF-4C, eukaryotic translation initiation factor 1A, Y-linked, eukaryotic translation initiation factor 1A Y-linked

External IDsOMIM: 400014; MGI: 1913485; HomoloGene: 100715; GeneCards: EIF1AY; OMA:EIF1AY - orthologs

Chr.Y chromosome (human)^[1]

End20,593,154 bp^[1]

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EIF1AY
Identifiers
Aliases	EIF1AY, eIF-4C, eukaryotic translation initiation factor 1A, Y-linked, eukaryotic translation initiation factor 1A Y-linked
External IDs	OMIM: 400014; MGI: 1913485; HomoloGene: 100715; GeneCards: EIF1AY; OMA:EIF1AY - orthologs
Gene location (Human) Chr. Y chromosome (human)[1] Band Yq11.223 Start 20,575,776 bp[1] End 20,593,154 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F4 Start 158,155,174 bp[2] End 158,172,924 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone vena cava apex of heart gonad rectum mucosa of transverse colon right lung testicle tendon of biceps brachii seminal vesicula Top expressed in otic placode saccule otic vesicle primitive streak hair follicle superior cervical ganglion medial ganglionic eminence maxillary prominence endothelial cell of lymphatic vessel mandibular prominence More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 9086 66235 Ensembl ENSG00000198692 ENSMUSG00000067194 UniProt O14602 Q8BMJ3 RefSeq (mRNA) NM_004681 NM_001278612 NM_025437 RefSeq (protein) NP_001265541 NP_004672 NP_079713 Location (UCSC) Chr Y: 20.58 – 20.59 Mb Chr X: 158.16 – 158.17 Mb PubMed search [3] [4]
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Like its X-chromosomal counterpart EIF1AX, it encodes an isoform of eukaryotic translation initiation factor 1A (EIF1A). EIF1A is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. It has one amino acid difference (M50L) from EIF1AX.^[6]