EIF4E3

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesEIF4E3, eIF-4E3, eIF4E-3, eukaryotic translation initiation factor 4E family member 3

External IDsOMIM: 609896; MGI: 1914142; HomoloGene: 41652; GeneCards: EIF4E3; OMA:EIF4E3 - orthologs

Chr.Chromosome 3 (human)^[1]

Quick facts Available structures, PDB ...

EIF4E3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B6U, 4B6V
Identifiers
Aliases	EIF4E3, eIF-4E3, eIF4E-3, eukaryotic translation initiation factor 4E family member 3
External IDs	OMIM: 609896; MGI: 1914142; HomoloGene: 41652; GeneCards: EIF4E3; OMA:EIF4E3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p13 Start 71,675,414 bp[1] End 71,754,773 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D3 Start 99,625,135 bp[2] End 99,666,771 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell tibialis anterior muscle deltoid muscle mucosa of ileum monocyte myocardium of left ventricle quadriceps femoris muscle gastrocnemius muscle vastus lateralis muscle biceps brachii Top expressed in primary oocyte secondary oocyte zygote interventricular septum Rostral migratory stream brown adipose tissue triceps brachii muscle temporal muscle myocardium of ventricle vastus lateralis muscle More reference expression data BioGPS n/a
Gene ontology Molecular function translation initiation factor activity RNA binding RNA 7-methylguanosine cap binding Cellular component cytoplasm cytosol mRNA cap binding complex eukaryotic translation initiation factor 4F complex Biological process translational initiation regulation of translation protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 317649 66892 Ensembl ENSG00000163412 ENSMUSG00000093661 UniProt Q8N5X7 Q9DBB5 RefSeq (mRNA) NM_001134649 NM_001134650 NM_001134651 NM_001282886 NM_173359 NM_025829 RefSeq (protein) NP_001128121 NP_001128122 NP_001128123 NP_001269815 NP_775495 NP_080105 Location (UCSC) Chr 3: 71.68 – 71.75 Mb Chr 6: 99.63 – 99.67 Mb PubMed search [3] [4]
Wikidata
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EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.^[5][6]