EIF4EBP2

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesEIF4EBP2, 4EBP2, PHASII, eukaryotic translation initiation factor 4E binding protein 2
Quick facts Available structures, PDB ...
EIF4EBP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4EBP2, 4EBP2, PHASII, eukaryotic translation initiation factor 4E binding protein 2
External IDsOMIM: 602224; MGI: 109198; HomoloGene: 3022; GeneCards: EIF4EBP2; OMA:EIF4EBP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004096

NM_010124

RefSeq (protein)

NP_004087
NP_004087.1

NP_034254

Location (UCSC)Chr 10: 70.4 – 70.43 MbChr 10: 61.26 – 61.29 Mb
PubMed search[3][4]
Wikidata
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Animal studies

EIF4EBP2 knockout mice have been used as an animal model of autism. Mice without the Eif4ebp2 gene exhibited autism-like symptoms, including poor social interaction, altered communication and repetitive behaviors. Knockout mice have high levels of Neuroligins.[8]

Interactions

EIF4EBP2 has been shown to interact with EIF4E.[5][9]

References

Further reading

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